研究领域

多能干细胞可分化为机体各种细胞类型，在再生医学领域进行细胞替代治疗以及组织/器官再生具有巨大潜能。本课题组致力于多能干细胞向心肌和骨骼肌分化的生物学基础与临床应用的研究。通过确定各类信号分子对其定向分化调控机理，探究分化早期发生的调控规律，为临床细胞移植应用提供新途径和理论依据。

1. PSC诱导分化心肌细胞体外筛选、鉴定、标记和增殖。

2. 以ESC诱导心肌细胞分化为体外模型结合模式动物研究与心脏发育及先心病相关的基因及机制。

3. RNA 结合蛋白在干细胞分化及心脏和骨骼肌发育中的转录后调控机制。

4 心肌病发生的分子机制：以干细胞分化为研究模型发现、鉴定致病新基因.

5. 制备病人特异性iPS体外细胞模型，研究相关疾病发生机制和药物筛选。

6. 干细胞联合纳米技术、新材料在生物医学的应用。

学习经历

1983-1987厦门大学生物系微生物专业本科

1987-1990福建师范大学生物化学专业硕士

1998-2001新加坡国立大学生物系分子生物学专业博士

工作经历

2001-2004 Genome Institute of Singapore 干细胞基因组实验室 Research fellow

2004-2007 胚胎干细胞国际公司心血管再生课题组高级科学家

2007-2011 新加坡医学生物研究所干细胞课题组负责人

2010-至今pc加拿大预测准确率特聘教授，干细胞与再生医学研究所副所长

代表性成果

1.Yu Lin, Kar Tong Tan, Jing Liu, Xu Kong, Zhengrong Huang, Xiu Qin Xu* (2017) Global profiling of Rbm24 bound RNAs uncovers a multi-tasking RNA binding protein. International Journal of Biochemistry and Cell Biology, 94 (2018) 10–21 (corresponding author).

2.Liu, J., Kong, X., et al, and Xu, XQ^* (2017) Stk38 Modulates Rbm24 Protein Stability to Regulate Sarcomere Assembly in Cardiomyocytes. Scientific Reports, 7:44870 (corresponding author).

3.Zhang, T., Lin, Y., Liu, J., Zhang, Z.G., Fu, W., Guo, L.Y., Pan, L., Kong, X., Zhang, M.K., Lu, Y.H., Zhang, R.H. Qiang, X., Wei, H.L., Xu, X.Q. Rbm24 regulates alternative splicing switch in Embryonic stem cell cardiac lineage differentiation. Stem cells. 2016, 34(7):1776-89. (corresponding author).

4.J Liu, L Wang, J Cao, Y Huang, Y Lin, XY Wu, Z Wang, F Zhang, XQ Xu*and G Liu，Functional investigations on embryonic stem cells labeled with clinically translatable iron oxide nanoparticles，Nanoscale, (2014) 6: 9025-9033 (corresponding author).

5.Xiu Qin Xu and William Sun, Perspective From the Heart: The Potential of Human Pluripotent Stem Cell-Derived Cardiomyocytes, J. Cell. Biochem. 114: 39–46, 2013. (corresponding author).

6.Xiu Qin Xu, Manasi Nandihalli, Kar Tong Tan, William Sun, “Cardiomyocytes from Human Embryonic Stem Cells” Book Chapter: Encyclopedia of Molecular Cell Biology and Molecular Medicine. 2013, Wiley-VCH Verlag GmbH & Co. KGaA. DOI: 10.1002/3527600906.mcb.201200007.

7.Kar Lai Poon;Kar Tong Tan; Yang Ye Wei; Chee Peng Ng; Alan Colman;Vladimir Korzh; Xiu Qin Xu* RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility. Cardiovascular Research (2012) 94：418-427 (corresponding author).

8.Wang, J., Huang, W., Xu, R., Nie, Y., Cao, X., Meng, J., Xu, X., Hu, S., and Zheng, Z., MicroRNA-24 regulates cardiac fibrosis after myocardial infarction. J Cell Mol Med, 2012. 16(9): p. 2150-60.

9.Xiu Qin Xu*, SY Soo, W Sun, R Zweigerdt. Global Expression Profile of Highly Enriched Cardiomyocytes Derived from Human Embryonic Stem Cells. Stem Cells (2009) 27: 2163-2174 (corresponding author).

10.Xiu Qin Xu*, R Graichen, C Mummery, Alan Colman, R Zweigerdt, B. Davidson. Chemically Defined Medium supporting Differentiation of Human Embryonic Stem Cells to Cardiomyocytes. Differentiation, (2008) 76: 958-970 (corresponding author).

11.Xiu Qin Xu*, R Zweigerdt, A Colman, and W Sun. Highly Enriched Cardiomyocytes from Human Embryonic Stem Cells. Cytotherapy, (2008) 10:376-89 (corresponding author).

12.RGraichen, Xiu Qin Xu, SY Soo, SC Tham, C Mummery, A Colman, R Zweigerdt, BP Davidson. Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK.Differentiation, (2008) 76:357-70.

13.KM, Mohankumar*, Xiu Qin Xu*, LD Miller, ET Liu, PD Gluckman, PE Lobie. HOXA1-stimulated oncogenicity is mediated by selective upregulation of components of the p44/42 MAP kinase pathway in human mammary carcinoma cells. Oncogene.(2007) 7:3998-4008 (*Equal first author).

14.Freund, C., D. Ward-van Oostwaard, J. Monshouwer-Kloots, S. van den Brink, M. van Rooijen, X.Q. Xu, R. Zweigerdt, C. Mummery, and R. Passier, Insulin redirects differentiation from cardiogenic mesoderm and endoderm to neuroectoderm in differentiating human embryonic stem cells. Stem Cells, 2008. 26(3): p. 724-33.

15.S Shin, Y Sun, Y Liu, Xiu Qin Xu, B Davidson, E Reubinoff, S Goldman, Z Ming, M Rao, J Chestnut, Whole Genome Analysis of Human Neural Stem Cells Derived from Embryonic Stem Cells and Stem and Progenitor Cells Isolated from Fetal Tissue. Stem Cells (2007)25: 1298-1306

16.X Zhang X Lu, Xiu-Qin Xu, HC Leung, WH. Wong. Recursive SVM Feature Selection and Sample Classification for Proteomics Mass-Spectrometry and microarray Data. BMC Bioinformatics (2006) 7:197

17.Xiu Qin Xu , BS Emerald, EL Goh, N. Kannan, LD Miller, PD Gluckman, Edison T Liu and P Lobie. Gene expression profiling to identify oncogenic determinants of autocrine human growth hormone (hGH) in human mammary carcinoma. Journal of Biological Chemistry. (2005) 280: 23987-24003

18.CL Wei, P Robson L. Stanton , SK Lim, Xiu-Qin Xu, Y J Ruan, M Rao. Bing Lim. Transcriptome Profiling of Human and Murine ESCs Identifies Divergent Paths Required to Maintain the Stem Cell State. Stem Cells. (2005) 23:166–185

19.Xiu-Qin Xu, X Lu, X. Zhang, JS. Liu, WH Wong, A Asperger, S Deininger, CK Leow, HC Leung (2004) Molecular Classification of Liver Cirrhosis in Rat Model by Proteomics and Bioinformatics. Proteomics (2004) 4: 3235-3245

20.Xiu Q. Xu and S. Q. Pan. Feedback regulation of Agrobacterium catalase gene katA involved in Agrobacterium-plant interaction. Molecular Microbiology (2001) 42: 645-657

21.Xiu. Q. Xu and S. Q. Pan An Agrobacterium catalase is a virulence factor involved in tumorigenesis. Molecular Microbiology (2000) 35: 407-14

主持过的重要课题：

1. 国家自然科学基金面上项目，项目负责人，2016

2. 年国家科技部重大科学研究计划973项目课题 “高效获得适于移植的hESCs衍生细胞及构建工程化心肌微组织” 课题负责人，2014

3. 国家自然科学基金面上项目，项目负责人，2013

4. 国家科技部863课题，“干细胞治疗技术临床转化及应用研究”，子课题负责人，2011

5. 深圳市科技计划项目，项目负责人，2017

已申请的专利：

1.“Direct differentiation of cardiomyocytes from human embryonic stem cells”(2007) WIPO (World International Property Organization) Pub. No.:WO/2007/070964

2.“CardiomyocyteProduction” (2007) WIPO (World International Property Organization) Pub. No.:WO/2007/030870

3.利用小分子化合物诱导干细胞向心肌分化的方法（2016），国内授权号：ZL 201410629278.5

4.RNA结合蛋白Rbm24基因在心肌病和心律失常中的应用（2017），国内申请号：201711495981.1

5.基于HCN4双报告基因获得多能干细胞衍生的高度纯化传导细胞的方法（2017）国内申请号：201711495969.0

6.一种基于Rbm24基因获得干细胞源骨骼肌细胞的方法（2017）国内申请号：201711496014.7