卓仁恭 助理教授 学科（方向）：药理学 所在系部：基础医学部 邮 箱：zhuorg@126.com
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研究领域：
阿尔茨海默病（AD）病理过程中神经元兴奋性和突触功能发生改变，已知神经调节蛋白1（Neuregulin 1，NRG1）及其受体ErbB4参与神经元兴奋性和突触可塑性调节并影响AD病理进程；双孔钾通道成员TREK通道受到多种细胞内信号通路的调控，降低或提高TREK通道活性均可调节神经元的兴奋性活动，从而对学习记忆功能产生影响。目前，正采用AD细胞和动物模型，研究NRG1及其受体ErbB4调控TREK通道影响神经元兴奋性和AD病理进程的机制，具体包括：(1)阐明NRG1-ErbB4信号通路对TREK通道的调节作用特点；(2)揭示NRG1-ErbB4信号通路是否通过调节TREK通道影响AD细胞模型和动物模型的神经元兴奋性；(3)揭示NRG1-ErbB4信号通路是否通过调节TREK通道影响AD模型的神经元兴奋性进而影响AD的病理进程，并阐明相关作用机制；
学习经历：
2006.09~2010.06 南方医科大学中药学专业 医学学士；
2010.09~2015.06 南方医科大学药理学专业 医学博士；
工作经历：
2015.09~2017.12 pc加拿大预测准确率 博士后；
2018.04~至今 pc加拿大预测准确率 助理教授；
代表性成果：
Zhuo RG, Peng P, Liu XY, Yan HT, Xu JP, Zheng JQ, Wei XL*, Ma XY*.Intersubunit Concerted Cooperative and cis-Type Mechanisms Modulate Allosteric Gating in Two-Pore-Domain Potassium Channel TREK-2. Front Cell Neuroscience.2016.00127. eCollection 2016.
Zhuo RG, Peng P, Liu XY, Yan HT, Xu JP, Zheng JQ, Wei XL*, Ma XY*. Allosteric coupling between proximal C-terminus and selectivity filter is facilitated by the movement of transmembrane segment 4 in TREK-2 channel. Scientific Reports,2016; 6:21248.
Zhuo RG, Liu XY, Zhang SZ, Wei XL, Zheng JQ, Xu JP*, Ma XY*. Insights into the stimulatory mechanism of 2-aminoethoxydiphenyl borate on TREK-2 potassium channel. Neuroscience, 2015; 300: 85-93.
主持过的重要课题：
国家自然科学基金青年项目，81601227，Neuregulin1-ErbB4调节TREK通道在阿尔茨海默病中的机制研究，2017/01-2019/12，17.0万元，在研，主持
中国博士后科学基金面上项目，2016M590596，NRG1-ErbB4调节TREK通道在阿尔茨海默病中的机制研究，2016/07-2018/06，8.0万元（一等资助），已结题。
所有论文列表：
(1) Zhuo RG, Peng P, Zheng JQ, Zhang YL, Wen L, Wei XL, Ma XY*.The glycine hinge of transmembrane segment 2 modulates the subcellular localization and gating properties in TREK channels. Biochemical and biophysical research communications, 2017 Aug 26;490(3):1125-1131. https://www.ncbi.nlm.nih.gov/pubmed/?term=The+glycine+hinge+of+transmembrane+segment+2+modulates+the+subcellular+localization+and+gating+properties+in+TREK+channels.
(2) Zhuo RG, Peng P, Liu XY, Yan HT, Xu JP, Zheng JQ, Wei XL*, Ma XY*. Intersubunit Concerted Cooperative and cis-Type Mechanisms Modulate Allosteric Gating in Two-Pore-Domain Potassium Channel TREK-2. Front Cell Neuroscience. 2016.00127. eCollection 2016. https://www.ncbi.nlm.nih.gov/pubmed?term=(Intersubunit%20Concerted%20Cooperative%20and%20cis-Type%20Mechanisms%20Modulate%20Allosteric%20Gating%20in%20Two-Pore-Domain%20Potassium%20Channel%20TREK-2.)
(3) Zhuo RG, Peng P, Liu XY, Yan HT, Xu JP, Zheng JQ, Wei XL*, Ma XY*. Allosteric coupling between proximal C-terminus and selectivity filter is facilitated by the movement of transmembrane segment 4 in TREK-2 channel. Scientific Reports,2016; 6:21248.
https://www.ncbi.nlm.nih.gov/pubmed/?term=Allosteric+coupling+between+proximal+C-terminus+and+selectivity+filter+is+facilitated+by+the+movement+of+transmembrane+segment+4+in+TREK-2+channel.
(4) Zhuo RG, Liu XY, Zhang SZ, Wei XL, Zheng JQ, Xu JP*, Ma XY*. Insights into the stimulatory mechanism of 2-aminoethoxydiphenyl borate on TREK-2 potassium channel. Neuroscience, 2015; 300: 85-93.
https://www.ncbi.nlm.nih.gov/pubmed/?term=Insights+into+the+stimulatory+mechanism+of+2-aminoethoxydiphenyl+borate+on+TREK-2+potassium+channel.
(5) Zhuo RG, Peng P, Liu XY, Zhang SZ, Xu JP, Zheng JQ, Wei XL*, Ma XY*. The isoforms generated by alternative translation initiation adopt similar conformation in the selectivity filter in TREK-2. Journal of physiology and biochemistry, 2015; 71(4):601-610. (IF=2.4440)
https://www.ncbi.nlm.nih.gov/pubmed/?term=The+isoforms+generated+by+alternative+translation+initiation+adopt+similar+conformation+in+the+selectivity+filter+in+TREK-2.
(6) Zhuo RG#, Ma XY#, Zhou PL, Liu XY, Zhang K, Wei XL, Yan HT, Xu JP, Zheng JQ*. Mas-related G protein-coupled receptor D is coupled to endogenous calcium-activated chloride channel in Xenopus oocytes. Journal of physiology and biochemistry, 2014; 70(1): 185-191.
https://www.ncbi.nlm.nih.gov/pubmed/?term=Mas-related+G+protein-coupled+receptor+D+is+coupled+to+endogenous+calcium-activated+chloride+channel+in+Xenopus+oocytes.
