张雪芹
厦门市拔尖人才，硕士生导师 研究方向：产科重大疾病（早产、妊娠期糖尿病） 分子机制与临床干预策略研究 所在系部：妇产科学系 办公电话：0592-26621719 邮 箱：wind459@126.com | 
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研究领域
本课题组致力于产科重大疾病（早产、妊娠期糖尿病）分子机制与临床干预策略研究，近期在Front Microbio, Diabetes Ther, Environ Int.等国际学术期刊上发表了系列研究论文，利用微生物组学、代谢组学、基因组学等相关技术，主要以临床样本为研究对象，深入阐明解析早产、妊娠期糖尿病的环境因素、发病机制与临床干预策略。为制定高级别临床指南提供依据。主要方向包括：
1. 基于生物信息学与分子生物学手段研究妊娠维持与分娩启动的分子调控机制及干预路径。
2. 探讨围产期环境暴露与妊娠期糖尿病关联的分子起始事件与不良结局通路，制定精准防控策略。
3. 基于多维组学方法挖掘产科重大疾病（产科出血、子痫前期、重症感染）早期预测标志物。
学习与工作经历
2009/9-至今，pc加拿大预测准确率硕士生导师。厦门大学附属妇女儿童医院副院长，厦门市产科质控中心主任。
2014/11-2014/12在美国旧金山太平洋医疗中心任访问学者。2011/4-2011/5在美国斯坦福大学参与患者安全培训项目.
2007/05-2007/12，加拿大卡尔加里医学院，访问学者。
代表性成果
1 Qiu Y, Zhang X*, Ni Y. Association between Polycystic Ovarian Syndrome and
Risk of Gestational Diabetes Mellitus: A Meta-Analysis. Gynecol Obstet Invest.
2022;87(2):150-158. doi: 10.1159/000521728. Epub 2022 Feb 16. PMID: 35172306.
2 Zhu Y, Qiu Y, Zhang X*. TKTL1 participated in malignant progression of cervical cancer cells via regulating AKT signal mediated PFKFB3 and thus
regulating glycolysis. Cancer Cell Int. 2021 Dec 18;21(1):678. doi:
10.1186/s12935-021-02383-z. PMID: 34922556; PMCID: PMC8684167.
3 Xin Y, Xie J, Nan B, Tang C, Xiao Y, Wu Q, Lin Y, Zhang X*, Shen H. Freeze-
Thaw Pretreatment Can Improve Efficiency of Bacterial DNA Extraction From
Meconium. Front Microbiol. 2021 Dec 9;12:753688. doi: 10.3389/fmicb.2021.753688. PMID: 34956118; PMCID: PMC8695897.
4 Xiao Y, Zhang X*. Association Between Maternal Glucose/Lipid Metabolism
Parameters and Abnormal Newborn Birth Weight in Gestational Diabetes Complicated by Preeclampsia: A Retrospective Analysis of 248 Cases. Diabetes Ther. 2020 Apr;11(4):905-914. doi: 10.1007/s13300-020-00792-3. Epub 2020 Feb 27. PMID: 32107704; PMCID: PMC7136359.
5 Qiu Y, Wu L, Xiao Y, Zhang X*. Clinical analysis and classification of
placental abruption. J Matern Fetal Neonatal Med. 2021 Sep;34(18):2952-2956.
doi: 10.1080/14767058.2019.1675625. Epub 2019 Oct 13. PMID: 31608779.
6 Li H, Qufeng W, Wei W, Lin X, Zhang X*. Umbilical artery thrombosis: Two case reports. Medicine (Baltimore). 2019 Nov;98(48):e18170. doi:
10.1097/MD.0000000000018170. Erratum in: Medicine (Baltimore). 2020
Jan;99(2):e18563. PMID: 31770267; PMCID: PMC6890325.
7 Zhang X, Xiao Y. The Association Between Trimester-Specific Weight Gain and
Severe Preeclampsia/Adverse Perinatal Outcome in Gestational Diabetes Mellitus
Complicated by Preeclampsia: A Retrospective Case Study. Diabetes Ther. 2019
Apr;10(2):725-734. doi: 10.1007/s13300-019-0589-3. Epub 2019 Mar 5. PMID:
30838548; PMCID: PMC6437224.
8 Lin LP, Niu GH, Zhang XQ*. Influence of lncRNA MALAT1 on septic lung injury in mice through p38 MAPK/p65 NF-κB pathway. Eur Rev Med Pharmacol Sci. 2019;23(3):1296-1304. doi:10.26355/eurrev_201902_17025
9 Wu Y, Zhang J, Peng S, Wang X, Luo L, Liu L, Huang Q, Tian M, Zhang X*, Shen H. Multiple elements related to metabolic markers in the context of gestational
diabetes mellitus in meconium. Environ Int. 2018 Dec;121(Pt 2):1227-1234. doi:
10.1016/j.envint.2018.10.044. Epub 2018 Oct 29. PMID: 30385065.
10 Zhang X, Xiao Y, Fan Y. Investigating the Reliability of HbA1c Monitoring for Blood Glucose Control During Late Pregnancy in Patients with Gestational Diabetes Mellitus (GDM) with and without β-Thalassemia Minor. Diabetes Ther. 2018 Dec;9(6):2305-2313. doi: 10.1007/s13300-018-0516-z. Epub 2018 Oct 4. PMID: 30284689; PMCID: PMC6250624.
承担的重要课题
1 国家自然科学基金委员会重点项目 胎盘维持母胎代谢互作稳态的细胞分子机制，82130047，2021-1至2024-12，骨干
2 国家自然科学基金委员会面上项目 碳黑颗粒的人体生物监测、跨胎盘迁 移和母胎效应研究， 22076158，2020-1至2023-12，骨干
3 国家重点研发计划 优化自发性早产的预测、预防以及治 疗 2018YFC1004 603。，2018-1至2021-12，参与
4 国家重点研发计划 产后出血术前评分模型及干预输血策略研究，2016YFC1000 406，2016-1至2019-12，参与
5 福建省自然科学基金面上项目：基于阴道微生态与宿主互作的免疫学特征分析宫颈环扎防治早产疗效的影响因素。2022D003，2022-9至2025-9，主持
6 中国疾控中心2022年度“母婴营养与健康研究项目”项目：妊娠期糖尿病患者孕期增重过多对新生儿肠道菌群特征的影响。2022FYH001，2022-9至2029-9，主持
7 厦门市医疗卫生重点项目，3502Z20191102，早产防诊治一体化的临床研究与应用。2019/11-2022/10。主持
8 厦门市科技局（科技惠民计划），2018S2334，不同分娩方式对子代肠道微生态及生长发育影响，2018/06-2021/06。主持
9 中国疾病预防控制中心妇幼保健中心，2016FY001，基于互联网+的多中心远程胎心监护和传统胎心监护一致性评价研究，2016/09-2017/05。主持
获奖及荣誉
1. 全国妇幼健康科学技术成果奖三等奖，2021年；
2. 厦门市科技进步二等奖，2020年；
3. 全国妇幼健康科学技术成果奖三等奖，2019年；
4. 厦门市拔尖人才，2020年
5. 中国医师协会授予“白求恩式好医生”，2018年
所有论文列表
1 Qiu Y, Zhang X*, Ni Y. Association between Polycystic Ovarian Syndrome and
Risk of Gestational Diabetes Mellitus: A Meta-Analysis. Gynecol Obstet Invest.
2022;87(2):150-158. doi: 10.1159/000521728. Epub 2022 Feb 16. PMID: 35172306.
2 Huang SY, Hsiao CH, Zhang XQ, Kang L, Yan JY, Cheng PJ. Serum procalcitonin to differentiate acute antepartum pyelonephritis from asymptomatic bacteriuria and acute cystitis during pregnancy: A multicenter prospective observational study. Int J Gynaecol Obstet. 2022 Jul;158(1):64-69. doi: 10.1002/ijgo.13955. Epub 2021 Oct 27. PMID: 34597439.
3 Zhu Y, Qiu Y, Zhang X*. TKTL1 participated in malignant progression of
cervical cancer cells via regulating AKT signal mediated PFKFB3 and thus
regulating glycolysis. Cancer Cell Int. 2021 Dec 18;21(1):678. doi:
10.1186/s12935-021-02383-z. PMID: 34922556; PMCID: PMC8684167.
4 Xin Y, Xie J, Nan B, Tang C, Xiao Y, Wu Q, Lin Y, Zhang X*, Shen H. Freeze-
Thaw Pretreatment Can Improve Efficiency of Bacterial DNA Extraction From
Meconium. Front Microbiol. 2021 Dec 9;12:753688. doi: 10.3389/fmicb.2021.753688.PMID: 34956118; PMCID: PMC8695897.
5 Lai S, Zhang X, Feng L, He M, Wang S. The prenatal diagnosis and genetic
counseling of chromosomal micro-duplication on 10q24.3 in a fetus: A case report
and a brief review of the literature. Medicine (Baltimore). 2020 Oct
16;99(42):e22533. doi: 10.1097/MD.0000000000022533. PMID: 33080687; PMCID:
PMC7571886.
6 Xiao Y, Zhang X*. Association Between Maternal Glucose/Lipid Metabolism
Parameters and Abnormal Newborn Birth Weight in Gestational Diabetes Complicated by Preeclampsia: A Retrospective Analysis of 248 Cases. Diabetes Ther. 2020 Apr;11(4):905-914. doi: 10.1007/s13300-020-00792-3. Epub 2020 Feb 27. PMID: 32107704; PMCID: PMC7136359.
7 Lin X, Yang T, Zhang X, Wei W. Lifestyle intervention to prevent gestational
diabetes mellitus and adverse maternal outcomes among pregnant women at high
risk for gestational diabetes mellitus. J Int Med Res. 2020
Dec;48(12):300060520979130. doi: 10.1177/0300060520979130. PMID: 33342331;
PMCID: PMC7756044.
8 Qiu Y, Wu L, Xiao Y, Zhang X*. Clinical analysis and classification of
placental abruption. J Matern Fetal Neonatal Med. 2021 Sep;34(18):2952-2956.
doi: 10.1080/14767058.2019.1675625. Epub 2019 Oct 13. PMID: 31608779.
9 Li H, Qufeng W, Wei W, Lin X, Zhang X*. Umbilical artery thrombosis: Two case reports. Medicine (Baltimore). 2019 Nov;98(48):e18170. doi:
10.1097/MD.0000000000018170. Erratum in: Medicine (Baltimore). 2020
Jan;99(2):e18563. PMID: 31770267; PMCID: PMC6890325.
10 Li X, Liu L, Wang H, Zhang X, Xiao T, Shen H. Phthalate exposure and
cumulative risk in a Chinese newborn population. Environ Sci Pollut Res Int.
2019 Mar;26(8):7763-7771. doi: 10.1007/s11356-019-04216-z. Epub 2019 Jan 23.
PMID: 30673950.
111 Wu Y, Zhang X, Zhang J, Zhang X, Shen H. [Metabolomic network analysis of
umbilical cord blood of gestational diabetes mellitus patients via liquid
chromatography-mass spectrometry]. Se Pu. 2019 Aug 8;37(8):897-903. Chinese.
doi: 10.3724/SP.J.1123.2019.02006. PMID: 31642261.
12 Zhang X, Xiao Y. The Association Between Trimester-Specific Weight Gain and
Severe Preeclampsia/Adverse Perinatal Outcome in Gestational Diabetes Mellitus
Complicated by Preeclampsia: A Retrospective Case Study. Diabetes Ther. 2019
Apr;10(2):725-734. doi: 10.1007/s13300-019-0589-3. Epub 2019 Mar 5. PMID:
30838548; PMCID: PMC6437224.
13 Lin LP, Niu GH, Zhang XQ*. Influence of lncRNA MALAT1 on septic lung injury in mice through p38 MAPK/p65 NF-κB pathway. Eur Rev Med Pharmacol Sci. 2019;23(3):1296-1304. doi:10.26355/eurrev_201902_17025
14 Wu Y, Zhang J, Peng S, Wang X, Luo L, Liu L, Huang Q, Tian M, Zhang X, Shen
H. Multiple elements related to metabolic markers in the context of gestational
diabetes mellitus in meconium. Environ Int. 2018 Dec;121(Pt 2):1227-1234. doi:
10.1016/j.envint.2018.10.044. Epub 2018 Oct 29. PMID: 30385065.
15 Zhang X, Xiao Y, Fan Y. Investigating the Reliability of HbA1c Monitoring for Blood Glucose Control During Late Pregnancy in Patients with Gestational Diabetes Mellitus (GDM) with and without β-Thalassemia Minor. Diabetes Ther. 2018 Dec;9(6):2305-2313. doi: 10.1007/s13300-018-0516-z. Epub 2018 Oct 4. PMID: 30284689; PMCID: PMC6250624.
16 Zhang B, Zhang X*, Wang Y. Idiopathic Chylous Ascites in Pregnancy: A Case
Report. Iran J Public Health. 2018 Jul;47(7):1034-1036. PMID: 30182003; PMCID:
PMC6119575.
17 Liu L, She J, Xueqin Zhang, Zhang J, Tian M, Huang Q, Shah Eqani SA, Shen H*. Online background cleanup followed by high-performance liquid chromatography with tandem mass spectrometry for the analysis of perfluorinated compounds in human blood. Journal of Separation Science, 2015, 38(2):247.
